Aclasta is a medicine used for the treatment and prevention of osteoporosis of various etiologies, including the treatment of women suffering from osteoporosis during menopause. Also recommended for the treatment of deforming osteitis (Paget's disease), male osteoporosis, reducing the number of fractures (hips, spine, others), strengthening the bone skeleton due to its property to increase bone tissue density.
Zoledronic acid, which is part of it, has the property of inhibiting bone resorption. Being similar in composition to mineralized bone tissue, it also has a selective effect. The duration of action of the drug is due to the increased bond of the specified acid with bone minerals, as well as the active center of its main molecular target - the enzyme farnesylpyrophosphatase.
When treated with this drug in patients with osteoporosis there is a fall in the level of metabolism in the bones, and after 12 weeks in women, it is restored to menopause. With an annual introduction, it is maintained at a stable level.
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What are the contraindications to the application Aclasta?
Contraindicated in allergies to Zoledronic acid, biophosphonates. Not prescribed in pediatric practice, with severe renal impairment. Caution is given to patients suffering from impaired mineral metabolism. Most often, the use of this drug causes hyperthermia, muscle, headache, joint pain, influenza symptoms. They usually develop in the first three days, increase with re-introduction, and decrease when taking non-steroidal anti-inflammatory drugs immediately after a drip. Аlso possible dyspeptic disorders, minor changes in the nervous system (paresthesia, anxiety, insomnia), skin and other allergic reactions may occur. Urinary system disorders may develop.
What dose of Aclasta is needed?
It is given intravenously, dropwise (in the form of infusions), for at least 15 minutes, warmed to room temperature. It is forbidden to use it simultaneously with other drugs in one system. The scheme of treatment (dosage, frequency of administration, duration of the course) is strictly individual, is prescribed by the doctor, based on the individual characteristics of the patient, the course of his illness, physical indicators.